Rheumatology, 2-Volume Set 8th Edition + Video


Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field.

Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field― all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases.

  • Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases.
  • Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases.
  • Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference.
  • Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics.
  • Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis.
  • Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology.
  • Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment.


State-of-the-art, balanced coverage of all aspects of rheumatology




Marc C. Hochberg MD MPH MACP







Size (mb)


1. The synovium
2. The articular cartilage
3. Bone structure and function
4. Tendons and ligaments
5. Biomechanics of peripheral joints and spine
6. Scientific basis of pain
7. Principles of innate immunity
8. Principles of adaptive immunity
9. Signal transduction in immune cells
10. Cytokines
11. Inflammation and its chemical mediators
12. The complement system
13. Osteoimmunology
14. Joint tissue destruction and proteolysis
15. Principles of tissue engineering and cell- and gene-based therapy
16. Big Data analysis
17. Principles and techniques in molecular biology
18. Proteomics
19. Metabolomics
20. Epigenetics
21. Precision medicine and pharmacogenomics in rheumatology
22. The microbiome in rheumatic diseases
23. Principles of epidemiology
24. Principles of clinical outcome assessment
25. Principles of health economics
26. Principles of genetic epidemiology
27. Interpreting the medical literature for the rheumatologist
28. Ethics in clinical trials
29. History and physical examination
30. Laboratory tests in rheumatic disorders


180. The epidemiology of coronavirus disease 2019 (COVID-19) and rheumatic disease
181. Epidemiology and classification of osteoarthritis
182. Local and systemic risk factors for incidence and progression of osteoarthritis
183. Clinical features of osteoarthritis
184. Animal models of osteoarthritis
185. Pathogenesis and pathology of osteoarthritis
186. Genetics and epigenetics of osteoarthritis
187. Imaging of osteoarthritis
188. Assessment of the patient with osteoarthritis and measurement of outcomes
189. Preclinical and early osteoarthritis
190. Management of osteoarthritis
191. Emerging treatments for osteoarthritis
192. Epidemiology and classification of gout
193. Etiology and pathogenesis of gout
194. Clinical features of gout
195. Management of gout and hyperuricemia
196. Calcium pyrophosphate deposition disease (pseudogout)
197. Basic calcium phosphate crystal deposition disease
198. Epidemiology and classification of osteoporosis
199. Clinical evaluation and clinical features of osteoporosis
200. Pathophysiology of osteoporosis
201. Biochemical markers of bone turnover in postmenopausal osteoporosis
202. Management of osteoporosis
203. Glucocorticoid-induced osteoporosis
204. Osteomalacia, rickets, and renal osteodystrophy
205. Paget disease of bone
206. Diffuse idiopathic skeletal hyperostosis
207. Neuropathic arthropathy
208. Osteonecrosis
209. Rheumatoid manifestations of endocrine and metabolic diseases and treatments
210. Hemophilia-associated arthritis
211. Rheumatologic manifestations of hemoglobinopathies
212. Hemochromatosis
213. Gaucher disease
214. Digital clubbing and hypertrophic osteoarthropathy
215. Miscellaneous arthropathies
216. Heritable connective tissue disorders
217. Hypermobility syndrome
218. Bone tumors